Best Way Out?

We chased our pleasures here
Dug our treasures there
But can you still recall
The time we cried
Break on through to the other side
--The Doors

One argument advanced by proponents of vaccine mandates is that vaccines are the best way out of pandemic conditions. To hold credence, this line of thought requires persuasive support, much of it scientific in nature. However, theory and evidence are far from conclusive with respect to vaccines. In fact, other alternatives garner substantial support.

The human body's primary natural line of defense against viral infection is the immune system. Immune systems are networks of biological processes that detect and respond to a variety of pathogens that threaten human health. Strong immune systems ward off infections and reduce the impact of infections that do occur. They are also adaptive, meaning that once they interact with pathogens they commonly build resistance against future invasion.

General factors associated with immune system strength are well known and largely life style related. Proper rest and nutrition. Exercise and fitness. Supplements such as Vitamin D and zinc can bolster immune system strength particularly during winter months when exposure to sunshine is reduced.

It should not be surprising that these customary principles of immune system strength appear to apply to the CV19 context. For example, studies have shown that Vitamin D deficiency is associated with CV19 mortality. Seasonality patterns associated with CV19 patterns are also evident. I have also seen several papers (not cited here) suggesting significant relationships between individual fitness levels and/or self-reported degrees of exercise and susceptibility to CV19 infection, hospitalization, and death. We also know, of course, that CV19 generally does far more damage to the elderly and those with serious comorbidities--a skew that coincides with generally compromised immune systems.

Their endogenous, preventative nature make immune systems an intuitive, and economical 'way out' of a pandemic. Why public health officials have not stressed the well established benefits of natural immune system health as a principle route away from the CV19 situation is dumbfounding and, thus, subject to speculation. What we do know is that initiatives to improve natural immunity are plausible alternatives to vaccines as countermeasures to a pandemic.

Another countermeasure involves therapeutics. Therapeutics are medicines that help you get well when you get sick. Therapeutics are primarily remedial in nature. In the context of CV19, monoclonal antibodies and ivermectin are among the remedies that have been employed to help people overcome infection.

Strangely, many public health agencies and officials have downplayed, and in some cases outright criticized, the efficacy of CV19 therapeutic treatments that clearly work in many cases. Regardless, therapeutics offer another proven measure of relief from pandemic conditions.

Assisted by therapeutics or not, people who overcome infections are prone to elevated levels of future resistance against similar illnesses. Once exposed to a pathogen, immune systems develop capacity to prevent recurrence of infection. This elevated resistance is commonly durable for long time periods. This leads us to yet another 'way out' of a pandemic supported by scientific principles: herd immunity.

The notion of herd immunity is intuitive. Thanks to our adaptive immune systems, it is difficult for us to get sick from the same pathogen twice in close by time frames. In the case of an infectious virus, as more people get sick from the virus and then recover, there are less hosts for virus to subsequently infect. At some threshold, enough people have contracted the virus and developed subsequent resistance to reinfection that it is difficult for the virus to subsequently spread. The herd has effectively become immune to the virus. 

Precisely what percentage of a population must contract a pathogen to achieve herd immunity has been subject to considerable scientific debate. Evidence suggests that herd immunity thresholds are pathogen dependent and may not be discernable until after the fact. What we do know is that cumulative infections create barriers to more infection, providing another route away from a pandemic. 

Compared to the above alternatives, a vaccine does not offer a clearly superior 'way out' of a pandemic--particularly in the case of CV19. The primary objective of a vaccine is motivate immune systems to develop defenses against particular infectious diseases. They typically do so by injecting agents into the body that resemble the disease-causing micro-organism. These agents are often sourced from weakened or dead forms of the microbe. The immune system detects the agent as a threat and then activates the usual self-defense mechanisms.

Finding the right agents for a vaccine--one that both provides effective defense against the pathogen with a safety profile free of significant side-effects--usually takes years. The time lag suggests the impracticality of building public health policy around the development of a effective, safe vaccine to combat a novel virus that creates pandemic conditions. By the time the vaccine is developed, the virus may have run its course. 

Enter the mRNA vaccines developed in response to CV19. Unlike traditional vaccines, prospective mRNA vaccines can be designed and produced in a matter of months--making them attractive as timely pandemic countermeasures. Unfortunately, the science associated with mRNA vaccines remains unproven. All previous mRNA projects have failed, meaning that vaccine candidates developed in response to the CV19 pandemic should be regarded as experimental in nature. 

One would think, then, that the allure of quick development time would be offset by a prolonged period of careful evaluation--extra careful in the case of an unproven, experimental vaccine technology. 

That hasn't happened. Instead, the CV19 vaccines were subjected to small numbers, short period, narrowly focused tests with little evaluation of long term effects, and rapidly 'approved' by regulatory agencies.

There is growing evidence that the CV19 vaccines provide, at best, short term protection against infection that erodes over the course of months. Natural immunity built from previous infection appears to be significantly more durable. There is also increasing evidence of undesirable side-effects.

Proponents of vaccine mandates, it seems, will need to reach for another argument, as ones based on scientific theory and evidence are unfavorable.